I think TweetDeck is more well known at the moment I use TweetDeck periodically and have not tried Seesmic Desktop yet. But this result is surprising because I've heard very good things about Seesmic Desktop in the past. I have to say I primarily use a Firefox extension called power twitter with twitter's actual website I like using the website directly the best. I use power twitter because it makes it easy to RT from twitter's website. But apparently twitters working on adding a native RT function so I might not need the Firefox extension soon
Thanks for reading my comment have a wonderful day everyone.